Literature summary extracted from

Fang, T.; Tian, Y.; Yuan, S.; Sheng, Y.; Arnesano, F.; Natile, G.; Liu, Y.
Differential reactivity of metal binding domains of copper ATPases towards cisplatin and colocalization of copper and platinum (2018), Chemistry, 24, 8999-9003 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
7.2.2.8	expression in Escherichia coli	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.2.2.8	cisplatin	comparison of different metal-binding domains of ATPases based on their reactivity towards cisplatin. The rate of platination is generally greater for holo-metal-binding domains than for apo-metal-binding domains. The platinum binding weakens the CuI coordination, but does not expel the copper ion from metal-binding domains; comparison of different metal-binding domains of ATPases based on their reactivity towards cisplatin. The rate of platination is generally greater for holo-metal-binding domains than for apo-metal-binding domains. The platinum binding weakens the CuI coordination, but does not expel the copper ion from metal-binding domains	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.2.2.8	Homo sapiens	P35670	-	-
7.2.2.8	Homo sapiens	Q04656	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
7.2.2.8	ATP7A	-	Homo sapiens
7.2.2.8	ATP7B	-	Homo sapiens
7.2.2.8	Menke's disease protein	-	Homo sapiens
7.2.2.8	Wilson disease protein	-	Homo sapiens

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Release 2023.1 (January 2023)